Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CHROMATIN

Embryogenesis without CTCF in flies and vertebrates

Nature Structural & Molecular Biology volume 28, pages 774–776 (2021)Cite this article

Subjects

CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Diagram of reported and potential impacts of CTCF on development.

References

  1. Lobanenkov, V. V. et al. Oncogene 5, 1743–1753 (1990).

    CAS  PubMed  Google Scholar 

  2. Heger, P. et al. Proc. Natl Acad. Sci. USA 109, 17507–17512 (2012).

    Article  CAS  Google Scholar 

  3. Arzate-Mejía, R. G., Recillas-Targa, F. & Corces, V. G. Development 145, dev137729 (2018).

    Article  Google Scholar 

  4. Braccioli, L. & de Wit, E. Essay. Biochem. 63, 157–165 (2019).

    Article  CAS  Google Scholar 

  5. van Ruiten, M. S. & Rowland, B. D. Current Opin. Cell Biol. 70, 84–90 (2021).

    Article  Google Scholar 

  6. Franke, M. et al. Nat. Commun. https://doi.org/10.1038/s41467-021-25604-5 (2021).

  7. Kaushal, A. et al. Nat. Commun. 12, 1011 (2021).

    Article  CAS  Google Scholar 

  8. Fedoriw, A. M. et al. Science 303, 238–240 (2004).

    Article  CAS  Google Scholar 

  9. Moore, J. M. et al. PLoS ONE 7, e34915 (2012).

    Article  CAS  Google Scholar 

  10. Andreu, M. J. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.07.07.451492 (2021).

  11. Gambetta, M. C. & Furlong, E. E. M. Genetics 210, 129–136 (2018).

    Article  CAS  Google Scholar 

  12. Kyrchanova, O. et al. Biochim. Biophys. Acta Gene Regul. Mech. 1864, 194733 (2021).

    Article  CAS  Google Scholar 

  13. Van Bortle, K. et al. Genome Biol. 15, R82 (2014).

    Article  Google Scholar 

  14. Rowley, M. J. & Corces, V. G. Nat. Rev. Genet. 19, 789–800 (2018).

    Article  CAS  Google Scholar 

  15. Li, Y. et al. Nature 578, 472–476 (2020).

    Article  CAS  Google Scholar 

  16. Nora, E. P. et al. Nat. Commun. 11, 5612 (2020).

    Article  CAS  Google Scholar 

  17. Nora, E. P. et al. Cell 169, 930–944 (2017).

    Article  CAS  Google Scholar 

  18. Kubo, N. et al. Nat. Struct. Mol. Biol. 28, 152–161 (2021).

    Article  CAS  Google Scholar 

  19. Olbrich, T. et al. Nat. Commun. 11, 4856 (2021).

    Article  Google Scholar 

  20. Carmona-Aldana, F. et al. Mech. Dev. 154, 51–59 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA

    Geoffrey Fudenberg

  2. Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA

    Elphège P. Nora

Authors
  1. Geoffrey Fudenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elphège P. Nora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Geoffrey Fudenberg or Elphège P. Nora.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fudenberg, G., Nora, E.P. Embryogenesis without CTCF in flies and vertebrates. Nat Struct Mol Biol 28, 774–776 (2021). https://doi.org/10.1038/s41594-021-00662-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-021-00662-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing