Recent advances in the ability to detect mRNA base modifications have led to a renewed appreciation for the diversity of the epitranscriptome and its ability to influence gene expression. Now, a study in Cell adds acetylated cytidine (ac4C) to the list, identifying it as a widespread mark in cellular mRNAs that influences both mRNA stability and translation.
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Choi, S.H., Meyer, K.D. Acetylation takes aim at mRNA. Nat Struct Mol Biol 25, 1067–1068 (2018). https://doi.org/10.1038/s41594-018-0159-9
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DOI: https://doi.org/10.1038/s41594-018-0159-9
