By using genetic admixture in the multi-omic analysis of postmortem brains from Black Americans, we show that genetic ancestry influences gene expression in the brain. Notably, we find enrichment of ancestry-associated genes for immune response and vascular function, but not neuronal function. Our findings have potential implications for stroke, Parkinson’s disease and Alzheimer’s disease.
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This is a summary of: Benjamin, K. J. M. et al. Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01636-0 (2024).
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Genetic ancestry contributes to gene expression in the brain. Nat Neurosci (2024). https://doi.org/10.1038/s41593-024-01645-z
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DOI: https://doi.org/10.1038/s41593-024-01645-z
