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SEX DIFFERENCES

Puberty reverses sex differences in learning

Nature Neuroscience volume 25, pages 134–135 (2022)Cite this article

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Adult male rodents have long been known to show stronger hippocampal long-term potentiation (LTP) and learning than females. Le et al. find that this sex difference is reversed in pre-pubescent animals, and identify a female-specific mechanism that increases LTP threshold and decreases spatial memory in females after puberty.

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Fig. 1: Schematic summary of the main results from Le et al.

References

  1. Gruene, T. M., Flick, K., Stefano, A., Shea, S. D. & Shansky, R. M. eLife 4, e11352 (2015).

    Article  Google Scholar 

  2. Tronson, N. C. & Keiser, A. A. Trends Neurosci. 42, 680–692 (2019).

    Article  CAS  Google Scholar 

  3. Chai, X. J. & Jacobs, L. F. Behav. Brain Res. 208, 336–342 (2010).

    Article  Google Scholar 

  4. Bettis, T. J. & Jacobs, L. F. Behav. Processes 82, 249–255 (2009).

    Article  Google Scholar 

  5. Wang, W. et al. J. Neurosci. 38, 7935–7951 (2018).

    Article  CAS  Google Scholar 

  6. Kight, K. & McCarthy, M. Biol. Sex Differ. 11, 30 (2020).

    Article  CAS  Google Scholar 

  7. Raznahan, A. & Disteche, C. M. Neurosci. Biobehav. Rev. 120, 28–47 (2021).

    Article  CAS  Google Scholar 

  8. Le, A. A. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-021-01001-5 (2011).

  9. Hyer, M. M. et al. Neurobiol. Stress 14, 100303 (2021).

    Article  CAS  Google Scholar 

  10. Gogos, A., Sbisa, A., Witkamp, D. & van den Buuse, M. Eur. J. Neurosci. 52, 2614–2626 (2020).

    Article  Google Scholar 

  11. Ferretti, M. T. et al. Nat. Rev. Neurol. 14, 457–469 (2018).

    Article  Google Scholar 

  12. Kornfield, S. L., Hantsoo, L. & Epperson, C. N. Curr. Psychiatry Rep. 20, 39 (2018).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Psychology Department, University of Michigan, Ann Arbor, MI, USA

    Natalie C. Tronson

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  1. Natalie C. Tronson
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Correspondence to Natalie C. Tronson.

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The author declares no competing interests.

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Tronson, N.C. Puberty reverses sex differences in learning. Nat Neurosci 25, 134–135 (2022). https://doi.org/10.1038/s41593-021-00986-3

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