Poll and colleagues examined the historical activity of hippocampal CA1 neurons during learning and memory recall using longitudinal two-photon in vivo imaging, providing evidence that extra neural ensemble activity disrupts memory recall in a mouse model of early Alzheimer’s disease.
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References
Henstridge, C. M., Hyman, B. T. & Spires-Jones, T. L. Nat. Rev. Neurosci. 20, 94–108 (2019).
Roy, D. S. et al. Nature 531, 508–512 (2016).
Poll, S. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-0652-4 (2020).
Josselyn, S. A. & Tonegawa, S. Science 367, eaaw4325 (2020).
Tanaka, K. Z. et al. Neuron 84, 347–354 (2014).
Ryan, T. J., Roy, D. S., Pignatelli, M., Arons, A. & Tonegawa, S. Science 348, 1007–1013 (2015).
Choi, J. H. et al. Science 360, 430–435 (2018).
Roy, D. S. et al. Cell 170, 1000–1012.e19 (2017).
Kitamura, T. et al. Science 356, 73–78 (2017).
Bastin, C., Delhaye, E., Moulin, C. & Barbeau, E. J. Neurosci. Biobehav. Rev. 100, 237–249 (2019).
Grudzien, A. et al. Neurobiol. Aging 28, 327–335 (2007).
Auld, D. S., Kornecook, T. J., Bastianetto, S. & Quirion, R. Prog. Neurobiol. 68, 209–245 (2002).
Acquas, E., Wilson, C. & Fibiger, H. C. J. Neurosci. 16, 3089–3096 (1996).
Takeuchi, T. et al. Nature 537, 357–362 (2016).
Okada, K., Nishizawa, K., Kobayashi, T., Sakata, S. & Kobayashi, K. Sci. Rep. 5, 1315 (2015).
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Kim, R., Yamamoto, N. & Kitamura, T. Extra neural ensemble disrupts memory recall. Nat Neurosci 23, 905–907 (2020). https://doi.org/10.1038/s41593-020-0673-z
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DOI: https://doi.org/10.1038/s41593-020-0673-z