By exploiting recent advances in modern artificial intelligence and large-scale functional genomic datasets, sequence-to-function models learn the relationship between genomic DNA and its multilayer gene regulatory functions. These models are poised to uncover mechanistic relationships across layers of cellular biology, which will transform our understanding of cis gene regulation and open new avenues for discovering disease mechanisms.
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We thank C. de Boer and X. Tu for helpful comments. ChatGPT was used to refine some of the sentences.
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Sasse, A., Chikina, M. & Mostafavi, S. Unlocking gene regulation with sequence-to-function models. Nat Methods 21, 1374–1377 (2024). https://doi.org/10.1038/s41592-024-02331-5
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DOI: https://doi.org/10.1038/s41592-024-02331-5
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