We developed, characterized and validated nLight sensors, a new family of genetically encoded green and red fluorescent norepinephrine indicators based on an alpha-1 adrenergic receptor. nLight probes can detect norepinephrine in living animals with superior sensitivity, ligand specificity and temporal resolution as compared with previous tools.
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References
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This is a summary of: Kagiampaki, Z. et al. Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nat. Methods https://doi.org/10.1038/s41592-023-01959-z (2023).
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Ultrafast nLight indicators for sensitive and specific in vivo imaging of norepinephrine. Nat Methods 20, 1289–1290 (2023). https://doi.org/10.1038/s41592-023-01960-6
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DOI: https://doi.org/10.1038/s41592-023-01960-6