Primary fetal organoids are currently derived from tissue samples obtained at termination of pregnancy. We developed an approach that enables prenatal derivation of epithelial organoids from fetal fluids. Single-cell mapping of the human amniotic fluid content unveiled the presence of viable fetal epithelial progenitors of multiple tissues that can form fetal lung, kidney and intestinal organoids.
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References
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This is a summary of: Gerli, M.F.M. et al. Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids. Nat. Med. https://doi.org/10.1038/s41591-024-02807-z (2024).
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Minimally invasive derivation of primary human epithelial organoids from fetal fluids. Nat Med 30, 648–649 (2024). https://doi.org/10.1038/s41591-024-02831-z
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DOI: https://doi.org/10.1038/s41591-024-02831-z
