Alzheimer’s disease is a complex and chronic disease that evolves over decades. Proteomic analysis of cerebrospinal fluid from people with dominantly inherited forms of the disease reveals the temporal progression of pathological changes in Alzheimer’s disease and identifies extracellular matrix proteins as some of the earliest biomarkers of the disease.
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References
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This is a summary of: Johnson, E. C. B. et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nat. Med. https://doi.org/10.1038/s41591-023-02476-4 (2023).
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Events in the brain during the evolution of Alzheimer’s disease. Nat Med 29, 1916–1917 (2023). https://doi.org/10.1038/s41591-023-02477-3
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DOI: https://doi.org/10.1038/s41591-023-02477-3
