The formation of a provisional matrix is required for the onset of tissue repair. New research shows that neutrophils carry pre-existing matrix across organs into wounds, promoting fibroblast activation and scar formation.
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Acknowledgements
The author would like to thank S. Z. Chong and J. L. L. Yao for critical reading of the manuscript. L.G.N. is supported by SIgN core funding. The author apologizes to the many colleagues whose contributions could not be discussed in this article.
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Ng, L.G. Neutrophils guide pre-existing matrix into injured organs to initiate tissue repair. Nat Immunol 23, 472–473 (2022). https://doi.org/10.1038/s41590-022-01173-7
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DOI: https://doi.org/10.1038/s41590-022-01173-7