Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunometabolism

One-carbon footprint in B cells

Nature Chemical Biology (2024)Cite this article

Subjects

Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant availability, purine synthesis and mTORC1 signaling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: MTHFD2 governs GC B cell responses by facilitating purine and GSH production.

References

  1. Vivas-García, Y. & Efeyan, A. Front. Mol. Biosci. 9, 991188 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Wu, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01690-6 (2024).

  3. Pardo-Lorente, N. & Sdelci, S. npj Metab. Health Dis. 2, 3 (2024).

    Article  Google Scholar 

  4. Ducker, G. S. et al. Cell Metab. 23, 1140–1153 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sugiura, A. et al. Immunity 55, 65–81.e9 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. Wheeler, M. L. & DeFranco, A. L. J. Immunol. 189, 4405–4416 (2012).

    Article  CAS  PubMed  Google Scholar 

  7. Wang, L. V. et al. Cell Metab. 30, 539–555.e11 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University Munich, Munich, Germany

    Rebekah Steiner & Julia Jellusova

Authors
  1. Rebekah Steiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julia Jellusova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julia Jellusova.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Steiner, R., Jellusova, J. One-carbon footprint in B cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01703-4

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41589-024-01703-4

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing