Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant availability, purine synthesis and mTORC1 signaling.
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Steiner, R., Jellusova, J. One-carbon footprint in B cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01703-4
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DOI: https://doi.org/10.1038/s41589-024-01703-4