Nature has evolved elegant enzymatic strategies to cyclize peptides, resulting in complex macrocyclic compounds with potent biological activities. A study illustrates the diverse chemical versatility of one such remarkable enzyme family, the cytochrome P450 macrocyclases, which form new biaryl crosslinks in ribosomal peptidic natural products.
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Pattanayakanahalli Henjarappa, K., Das, S. & Mahanta, N. A new class of macrocyclic peptides. Nat Chem Biol 20, 136–139 (2024). https://doi.org/10.1038/s41589-023-01507-y
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DOI: https://doi.org/10.1038/s41589-023-01507-y