Terpenoids bearing carbon skeletons derived from nonisoprene units are rare and considered noncanonical. Now, a genome-mining study has uncovered previously unknown noncanonical C16 terpenes and their biosynthetic pathways from bacteria. The findings suggest that noncanonical terpenoids are diverse and widespread in nature.
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Liu, S., Lara, D. & Hai, Y. Mining the noncanonical terpenome. Nat Chem Biol 19, 1440–1442 (2023). https://doi.org/10.1038/s41589-023-01486-0
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DOI: https://doi.org/10.1038/s41589-023-01486-0
