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Mitochondrial cofactor synthesis

Ferredoxins at the crossroads

Ferredoxins are universal electron donors. A study focusing on the two human mitochondrial ferredoxins reveals the existence of unique cellular functions and partners for each protein.

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Fig. 1: Mitochondrial ferredoxins from mammals possess specific, non-overlapping functions.

References

  1. Schulz, V. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01159-4 (2022).

    Article  Google Scholar 

  2. Ewen, K. M., Ringle, M. & Bernhardt, R. IUBMB Life 64, 506–512 (2012).

    Article  CAS  Google Scholar 

  3. Sheftel, A. D. et al. Proc. Natl Acad. Sci. USA 107, 11775–11780 (2010).

    Article  CAS  Google Scholar 

  4. Webert, H. et al. Nat. Commun. 5, 5013 (2014).

    Article  CAS  Google Scholar 

  5. Gervason, S. et al. Nat. Commun. 10, 3566 (2019).

    Article  Google Scholar 

  6. Weiler, B. D. et al. Proc. Natl Acad. Sci. USA 117, 20555–20565 (2020).

    Article  CAS  Google Scholar 

  7. Jain, A., Singh, A., Maio, N. & Rouault, T. A. Hum. Mol. Genet. 29, 3165–3182 (2020).

    Article  CAS  Google Scholar 

  8. Shi, Y., Ghosh, M., Kovtunovych, G., Crooks, D. R. & Rouault, T. A. Biochim. Biophys. Acta 1823, 484–492 (2012).

    Article  CAS  Google Scholar 

  9. Cai, K., Tonelli, M., Frederick, R. O. & Markley, J. L. Biochemistry 56, 487–499 (2017).

    Article  CAS  Google Scholar 

  10. Müller, J. J., Lapko, A., Bourenkov, G., Ruckpaul, K. & Heinemann, U. J. Biol. Chem. 276, 2786–2789 (2001).

    Article  Google Scholar 

Download references

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Correspondence to Nicolas Rouhier.

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Rouhier, N. Ferredoxins at the crossroads. Nat Chem Biol 19, 129–130 (2023). https://doi.org/10.1038/s41589-022-01176-3

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