A fungal ten-eleven translocation (TET) dioxygenase homolog, CcTet, is found to have both 5-methylcytosine (5mC) and N6-methyladenine (6mA) demethylase activity. Structure-based engineering of CcTet yielded a 6mA-specific demethylase, offering a useful tool for the manipulation and functional study of 6mA.
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Change history
07 July 2022
A Correction to this paper has been published: https://doi.org/10.1038/s41589-022-01099-z
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Li, S., Du, J. Making a 6mA demethylase. Nat Chem Biol 18, 683–684 (2022). https://doi.org/10.1038/s41589-022-01042-2
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DOI: https://doi.org/10.1038/s41589-022-01042-2
