Cell-free biosensing is emerging as an effective and low-cost technology, but interpretation and synthesis of the results remains largely manual. Now, researchers have incorporated a new information-processing layer between biosensors and their outputs using logic gates to integrate complex results.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zhang, D. Y. & Seelig, G. Nat. Chem. 3, 103–113 (2011).
Zhao, S. et al. Nanoscale Horiz. 6, 298–310 (2021).
Jung, J. K., Archuleta, C. M., Alam, K. K. & Lucks, J. B. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00962-9 (2022).
Jung, J. K. et al. Nat. Biotechnol. 38, 1451–1459 (2020).
Rodríguez-Serrano, A. F. & Hsing, I. M. ACS Synth. Biol. 10, 371–378 (2021).
Qian, L. & Winfree, E. Science 332, 1196–1201 (2011).
Schaffter, S. W. et al. Nucleic Acids Res. 46, 5332–5343 (2018).
Mitchler, M. M., Garcia, J. M., Montero, N. E. & Williams, G. J. Curr. Opin. Biotechnol. 69, 172–181 (2021).
Nguyen, P. Q. et al. Nat. Biotechnol. 39, 1366–1374 (2021).
Gräwe, A. et al. PLoS ONE 14, e0210940 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Amalfitano, E., Pardee, K. Logic invades cell-free biosensing. Nat Chem Biol 18, 356–358 (2022). https://doi.org/10.1038/s41589-021-00963-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-021-00963-8
