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ENZYMOLOGY

A complex struggle for direction

Nature Chemical Biology volume 18, pages 119–120 (2022)Cite this article

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To avoid strife at the interface of basic carbon and nitrogen metabolism, Bacillus subtilis has developed a rather combative solution. If needed, its glutamate synthase suppresses conflicting glutamate breakdown by directly binding and immobilizing its metabolic opponent, glutamate dehydrogenase.

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Fig. 1: The GudB–GltAB counter-enzyme system at the intersection of carbon and nitrogen metabolism.

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Authors and Affiliations

  1. Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany

    Marcus D. Hartmann

  2. Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

    Marcus D. Hartmann

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  1. Marcus D. Hartmann
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Correspondence to Marcus D. Hartmann.

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Hartmann, M.D. A complex struggle for direction. Nat Chem Biol 18, 119–120 (2022). https://doi.org/10.1038/s41589-021-00937-w

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