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RiPP-ing through the plant kingdom

An autocatalytic peptide cyclase defines a new subclass of plant ribosomally synthesized and post-translationally modified peptides (RiPPs). This discovery explains the origins of a large family of cyclic peptides and inspires new tools for mining these RiPPs across the plant kingdom.

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Fig. 1: Side-chain-macrocyclized RiPPs.

References

  1. Montalban-Lopez, M. et al. Nat. Prod. Rep. 38, 130–239 (2021).

    Article  CAS  Google Scholar 

  2. Daly, N. L. & Wilson, D. T. Biochem. Soc. Trans. 49, 1279–1285 (2021).

    Article  CAS  Google Scholar 

  3. Kersten, R. D. & Weng, J. K. Proc. Natl Acad. Sci. USA 115, E10961–E10969 (2018).

    Article  CAS  Google Scholar 

  4. Chigumba, D. N. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00892-6 (2021).

  5. van der Velden, N. S. et al. Nat. Chem. Biol. 13, 833–835 (2017).

    Article  Google Scholar 

  6. Song, H. et al. Sci. Adv. 4, eaat2720 (2018).

    Article  CAS  Google Scholar 

  7. Schramma, K. R., Bushin, L. B. & Seyedsayamdost, M. R. Nat. Chem. 7, 431–437 (2015).

    Article  CAS  Google Scholar 

  8. Ye, Y. et al. Org. Biomol. Chem. 17, 39–43 (2018).

    Article  Google Scholar 

  9. Kautsar, S. A. et al. Nucleic Acids Res. 45, W55–W63 (2017).

    Article  CAS  Google Scholar 

  10. Kessler, S. C. et al. Proc. Natl Acad. Sci. USA 117, 24243–24250 (2020).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Yit-Heng Chooi.

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Chooi, YH. RiPP-ing through the plant kingdom. Nat Chem Biol 18, 2–3 (2022). https://doi.org/10.1038/s41589-021-00901-8

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