An autocatalytic peptide cyclase defines a new subclass of plant ribosomally synthesized and post-translationally modified peptides (RiPPs). This discovery explains the origins of a large family of cyclic peptides and inspires new tools for mining these RiPPs across the plant kingdom.
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References
Montalban-Lopez, M. et al. Nat. Prod. Rep. 38, 130–239 (2021).
Daly, N. L. & Wilson, D. T. Biochem. Soc. Trans. 49, 1279–1285 (2021).
Kersten, R. D. & Weng, J. K. Proc. Natl Acad. Sci. USA 115, E10961–E10969 (2018).
Chigumba, D. N. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00892-6 (2021).
van der Velden, N. S. et al. Nat. Chem. Biol. 13, 833–835 (2017).
Song, H. et al. Sci. Adv. 4, eaat2720 (2018).
Schramma, K. R., Bushin, L. B. & Seyedsayamdost, M. R. Nat. Chem. 7, 431–437 (2015).
Ye, Y. et al. Org. Biomol. Chem. 17, 39–43 (2018).
Kautsar, S. A. et al. Nucleic Acids Res. 45, W55–W63 (2017).
Kessler, S. C. et al. Proc. Natl Acad. Sci. USA 117, 24243–24250 (2020).
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Chooi, YH. RiPP-ing through the plant kingdom. Nat Chem Biol 18, 2–3 (2022). https://doi.org/10.1038/s41589-021-00901-8
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DOI: https://doi.org/10.1038/s41589-021-00901-8