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GPCR STRUCTURAL BIOLOGY

Lighting up cholecystokinin

Nature Chemical Biology volume 17, pages 1213–1214 (2021)Cite this article

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Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.

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Fig. 1: Ligand recognition modes dictate distinct signaling pathways of cholecystokinin receptors.

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Authors and Affiliations

  1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Lin Cheng & Zhenhua Shao

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  1. Lin Cheng
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  2. Zhenhua Shao
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Correspondence to Zhenhua Shao.

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The authors declare no competing interests.

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Cheng, L., Shao, Z. Lighting up cholecystokinin. Nat Chem Biol 17, 1213–1214 (2021). https://doi.org/10.1038/s41589-021-00857-9

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