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CHEMOPROTEOMICS

Sweetly profiling the cysteinome

Nature Chemical Biology volume 15, pages 935–936 (2019)Cite this article

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A new sugar-based cysteine-reactive probe, combined with competitive activity-based protein profiling (ABPP), enables site-centric target deconvolution of itaconate in native proteomes, shedding light on a novel mechanism of action for this important immunoregulatory metabolite in inflammatory macrophages.

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Fig. 1: Chemoproteomics reveals a novel mechanism of action of itaconate in macrophages.

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  1. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences • Beijing, Beijing Institute of Lifeomics, Beijing, China

    Jing Yang

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  1. Jing Yang
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Correspondence to Jing Yang.

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Yang, J. Sweetly profiling the cysteinome. Nat Chem Biol 15, 935–936 (2019). https://doi.org/10.1038/s41589-019-0348-9

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