Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.
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Zhou, Y.J. Expanding the terpenoid kingdom. Nat Chem Biol 14, 1069–1070 (2018). https://doi.org/10.1038/s41589-018-0167-4
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DOI: https://doi.org/10.1038/s41589-018-0167-4
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