Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Engineering the oleaginous yeast Yarrowia lipolytica for production of α-farnesene
Biotechnology for Biofuels Open Access 23 December 2019
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Federova, O. et al. Nat Chem. Biol. https://doi.org/10.1038/s41589-018-0142-0 (2018).
Blount, K. F. & Breaker, R. R. Nat. Biotechnol. 24, 1558–1564 (2006).
Guan, L. & Disney, M. D. ACS Chem. Biol. 7, 73–86 (2012).
Palacino, J. et al. Nat. Chem. Biol. 11, 511–517 (2015).
Seiler, M. et al. Nat. Med. 24, 497–504 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author is an employee at H3 Biomedicine.
Rights and permissions
About this article
Cite this article
Palacino, J. The splice is right. Nat Chem Biol 14, 1068–1069 (2018). https://doi.org/10.1038/s41589-018-0147-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-018-0147-8
This article is cited by
-
Engineering the oleaginous yeast Yarrowia lipolytica for production of α-farnesene
Biotechnology for Biofuels (2019)