Multi-modal single-cell sequencing enables mapping of mutant and wild-type human hematopoietic stem and progenitor cells within the same person, to define cellular phenotypic and epigenetic perturbations associated with clonal hematopoiesis.
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References
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This is a summary of: Nam, A. S. et al. Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat. Genet. https://doi.org/10.1038/s41588-022-01179-9 (2022).
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Somatic mosaicism rewires transcriptional and epigenetic states in clonal hematopoiesis. Nat Genet 54, 1453–1454 (2022). https://doi.org/10.1038/s41588-022-01181-1
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DOI: https://doi.org/10.1038/s41588-022-01181-1
