Chromosomes are shaped by an interplay between loop extrusion and compartmentalization. Two new studies demonstrate that bromodomain and extraterminal domain (BET) proteins contribute to both processes, with BRD4 facilitating one process and surprisingly inhibiting the other.
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Acknowledgements
K.P.E. is grateful to B. Di Stefano, R. J. Parchem and M. L. K. Williams for critical reading of the manuscript and apologizes to those whose work could not be cited due to space limitations. Research in the Eagen laboratory is supported by an NIH Director’s Early Independence Award (DP5OD024587) and a Cancer Prevention & Research Institute of Texas Recruitment of First-Time, Tenure-Track Faculty Member Award (RR210082).
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Eagen, K.P. BET proteins loop and compartmentalize the 3D genome. Nat Genet 54, 370–371 (2022). https://doi.org/10.1038/s41588-022-01031-0
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DOI: https://doi.org/10.1038/s41588-022-01031-0