We developed synthetic serum markers that can be expressed in the brain but are transported into the blood, enabling minimally invasive monitoring of gene expression in the brain with a simple blood test.
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References
Alfaro, J. A. et al. The emerging landscape of single-molecule protein sequencing technologies. Nat. Methods 18, 604–617 (2021). This review presents technologies for single-molecule protein sequencing.
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This is a summary of: Lee, S. et al. Engineered serum markers for non-invasive monitoring of gene expression in the brain. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02087-x (2024).
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Monitoring gene expression in the brain with a blood test. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02088-w
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DOI: https://doi.org/10.1038/s41587-023-02088-w