In a ground-breaking development, rat kidneys have been cryopreserved for an unprecedented duration of 100 days and subsequently transplanted successfully after nano-rewarming. This extraordinary achievement opens new possibilities for the field of organ banking.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Giwa, S. et al. The promise of organ and tissue preservation to transform medicine. Nat. Biotechnol. 35, 530–542 (2017).
Han, Z. et al. Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model. Nat. Commun. 14, 3407 (2023).
Huang, H., He, X. & Yarmush, M. L. Advanced technologies for the preservation of mammalian biospecimens. Nat. Biomed. Eng. 5, 793–804 (2021).
Manuchehrabadi, N. et al. Improved tissue cryopreservation using inductive heating of magnetic nanoparticles. Sci. Transl. Med. 9, eaah4586 (2017).
Chiu-Lam, A., Staples, E., Pepine, C. J. & Rinaldi, C. Perfusion, cryopreservation, and nanowarming of whole hearts using colloidally stable magnetic cryopreservation agent solutions. Sci. Adv. 7, eabe3005 (2021).
Moers, C. et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N. Engl. J. Med. 360, 7–19 (2009).
Eshmuminov, D. et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol. 38, 189–198 (2020).
Hosgood, S. A. et al. Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial. Nat. Med. 29, 1511–1519 (2023).
Brasile, L., Stubenitsky, B. M., Booster, M. H., Haisch, C. & Kootstra, G. NOS: the underlying mechanism preserving vascular integrity and during ex vivo warm kidney perfusion. Am. J. Transplant. 3, 674–679 (2003).
de Vries, R. J. et al. Supercooling extends preservation time of human livers. Nat. Biotechnol. 37, 1131–1136 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
de Haan, M.J.A., Rabelink, T.J. Cryopreservation breaks the organ transplant time barrier. Nat Rev Nephrol 19, 623–624 (2023). https://doi.org/10.1038/s41581-023-00750-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41581-023-00750-9