Kidney failure is a serious but rare consequence of progressive chronic kidney disease. A meta-analysis of individual participant-level trial data, across heterogeneous treatments and disease groups, has shown glomerular filtration rate (GFR) slope to be a valid, fit-for-purpose and robust surrogate marker of kidney failure.
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J.S.L. has received personal lectureship honoraria from Astra Zeneca, Pfizer and Bristol Myers Squibb. P.B.M. reports lecture fees and/or fees for participating advisory boards and trial end point committees from Vifor, GSK, Astra Zeneca, Pharmacomsos, Napp, Astellas and Boehringer Ingelheim, and grants from Boehringer Ingelheim.
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Lees, J.S., Mark, P.B. GFR slope as a surrogate marker for future kidney failure. Nat Rev Nephrol 19, 625–626 (2023). https://doi.org/10.1038/s41581-023-00748-3
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DOI: https://doi.org/10.1038/s41581-023-00748-3