Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanatomical and transcriptomic alterations associated with long COVID could stem from this neuroendocrine perturbation.
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Change history
05 February 2024
A Correction to this paper has been published: https://doi.org/10.1038/s41574-024-00961-5
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Acknowledgements
The authors acknowledge the support of the European Research Council ERC-Synergy-Grant-2019-WATCH No. 810331 (to R.N., V. P. and M.S.), the Agence Nationale de la Recherche en Santé et la Fondation pour la Recherche Médicale (No. ECTZ200878 Long Covid 2021 ANRS0167 SIGNAL to V.P., M.S. and R.N.) and the European Union Horizon 2020 research and innovation program No. 847941 miniNO (to V.P.).
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Rasika, S., Nogueiras, R., Schwaninger, M. et al. Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits. Nat Rev Endocrinol 20, 189–190 (2024). https://doi.org/10.1038/s41574-024-00955-3
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DOI: https://doi.org/10.1038/s41574-024-00955-3