Pancreatic islet cell replacement therapy is a promising strategy for patients with type 1 diabetes mellitus, but the scarcity of organ donors and need for immunosuppression hamper its wide application. Huang and colleagues developed an efficient method to redirect the fate of primary human gastric stem cells, generated from stomach tissue, towards insulin-producing β-cells.
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Acknowledgements
F.C. and E.J.P.d.K. acknowledge the support of research funding from the RegMedXB consortium, DON foundation, the Dutch Diabetes Research Foundation, Bontius Foundation, JDRF and Novo Nordisk Foundation Center for Stem Cell Medicine (NNF21CC0073729).
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de Koning, E.J.P., Carlotti, F. Human stomach tissue as alternative source of insulin-producing cells. Nat Rev Endocrinol 19, 503–504 (2023). https://doi.org/10.1038/s41574-023-00867-8
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DOI: https://doi.org/10.1038/s41574-023-00867-8
