Host–microorganism circadian dynamics are key contributors to metabolic health. In addition, diet composition and timed feeding affect gut microbiota diurnal rhythms, with high-fat diets altering the composition of the gut microbiota and dampening circadian rhythms throughout the intestine. A recent study shows that time-restricted feeding of a high-fat diet restores the rhythms of small bowel host–microorganism interactions, preventing diet-induced obesity in mice.
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V.A.L. is supported by NIH NIDDK K01 DK111785.
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Tolba, S.A., Leone, V.A. Timed high-fat diet feeding restores small bowel circadian rhythms. Nat Rev Endocrinol 18, 721–722 (2022). https://doi.org/10.1038/s41574-022-00759-3
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DOI: https://doi.org/10.1038/s41574-022-00759-3
