A new paper explores genetic risk factors for polycystic ovary syndrome (PCOS) and non-reproductive PCOS phenotypes in women and men. This work affirms that PCOS is indeed a metabolic disorder, that ovarian function is not required for cardiometabolic features and that this condition has implications for both men and women.
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References
Teede, H. et al. International evidence-based guideline for the assessment and management of polycystic ovary syndrome. monash.edu. https://www.monash.edu/__data/assets/pdf_file/0004/1412644/PCOS_Evidence-Based-Guidelines_20181009.pdf (2018).
Yilmaz, B., Vellanki, P., Ata, B. & Yildiz, B. O. Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil. Steril. 110, 523–533.e14 (2018).
Yilmaz, B., Vellanki, P., Ata, B. & Yildiz, B. O. Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil. Steril. 109, 356–364.e32 (2018).
Lenarcik, A., Bidzińska-Speichert, B., Tworowska-Bardzińska, U. & Krępuła, K. Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS). Endokrynol. Pol. 62, 129–133 (2011).
Zhu, J. et al. Evidence from men for ovary-independent effects of genetic risk factors for polycystic ovary syndrome. J. Endocrinol. Metab. https://doi.org/10.1210/clinem/dgab838 (2021).
Gorsic, L. K., Dapas, M., Legro, R. S., Hayes, M. G. & Urbanek, M. Functional genetic variation in the anti-müllerian hormone pathway in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 104, 2855–2874 (2019).
Dapas, M. et al. Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis. PLoS Med. 17, e1003132 (2020).
Day, F. et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 14, e1007813 (2018).
Berni, T. R., Morgan, C. L. & Rees, D. A. Women with polycystic ovary syndrome have an increased risk of major cardiovascular events: a population study. J. Clin. Endocrinol. Metab. 106, e3369–e3380 (2021).
Joo, Y. Y. et al. A polygenic and phenotypic risk prediction for polycystic ovary syndrome evaluated by phenome-wide association studies. J. Clin. Endocrinol. Metab. 105, 1918–1936 (2020).
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Joham, A.E., Teede, H.J. PCOS — a metabolic condition with health impacts on women and men. Nat Rev Endocrinol 18, 197–198 (2022). https://doi.org/10.1038/s41574-022-00636-z
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DOI: https://doi.org/10.1038/s41574-022-00636-z
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