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CLINICAL TRIALS

Non-fatal MI as surrogate end point for all-cause or cardiovascular mortality

Nature Reviews Cardiology volume 19, pages 149–150 (2022)Cite this article

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In a pooled analysis of 144 high-quality randomized trials involving patients with coronary artery disease, application of the most stringent criteria for surrogacy demonstrated that a reduction in the rates of non-fatal myocardial infarction by any intervention did not necessarily predict a reduction in all-cause or cardiovascular mortality during follow-up.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Azienda Ospedaliero Universitaria Policlinico ‘G. Rodolico-San Marco’, University of Catania, Catania, Italy

    Davide Capodanno

  2. The Lambe Institute for Translational Medicine, Smart Sensors Laboratory and CÚRAM, Saolta University Healthcare Group, National University of Ireland, Galway, Ireland

    William Wijns

Authors
  1. Davide Capodanno
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  2. William Wijns
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Correspondence to William Wijns.

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The authors declare no competing interests.

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Capodanno, D., Wijns, W. Non-fatal MI as surrogate end point for all-cause or cardiovascular mortality. Nat Rev Cardiol 19, 149–150 (2022). https://doi.org/10.1038/s41569-021-00667-5

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