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Cell migration

Cells play tug-of-war to start moving collectively

Orderly or coherent multicellular flows are fundamental in biology, but their triggers are not understood. In epithelial tissues, the tug-of-war between cells is now shown to lead to intrinsic asymmetric distributions in cell polarities that drive such flows.

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Fig. 1: Spontaneous and coherent multicellular flows in epithelia.

References

  1. Stramer, B. & Mayor, R. Nat. Rev. Mol. Cell Biol. 18, 43–55 (2017).

    Article  PubMed  Google Scholar 

  2. Lo Vecchio, S., Pertz, O., Szopos, M., Navoret, L. & Riveline, D. Nat. Phys. https://doi.org/10.1038/s41567-023-02295-x (2024).

  3. Trepat, X. et al. Nat. Phys. 5, 426–430 (2009).

    Article  CAS  Google Scholar 

  4. Turing, A. M. Phil. Trans. R. Soc. Lond. B 237, 37–72 (1952).

    Article  ADS  Google Scholar 

  5. Arnold, T. R., Stephenson, R. E. & Miller, A. L. Exp. Cell Res. 358, 20–30 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lomakin, A. J. et al. Nat. Cell Biol. 17, 1435–1445 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lecuit, T. & Yap, A. S. Nat. Cell Biol. 17, 533–539 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Murrell, M., Oakes, P. W., Lenz, M. & Gardel, M. L. Nat. Rev. Mol. Cell. Biol. 16, 486–498 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wu, Y. I. et al. Nature 461, 104–108 (2009).

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Download references

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Correspondence to Guillermo A. Gomez.

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Gomez, G.A. Cells play tug-of-war to start moving collectively. Nat. Phys. 20, 189–190 (2024). https://doi.org/10.1038/s41567-023-02314-x

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