The host protein cyclophilin A binds to the HIV-1 capsid and its role in infection has long been enigmatic. A new study shows that this interaction protects the virus from inhibition by TRIM5α in physiologically relevant primary human cells.
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Aiken, C. Shielding the HIV-1 capsid. Nat Microbiol 5, 12–13 (2020). https://doi.org/10.1038/s41564-019-0638-8
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DOI: https://doi.org/10.1038/s41564-019-0638-8