Inferring the evolutionary history of prokaryotic pangenomes is complicated by the lack of a reference for neutral genetic variation. A study that uses pseudogenes as a neutral reference provides support for selection as a force that shapes pangenomes.
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Domingo-Sananes, M.R., Meehan, C.J. The population genetics of prokaryotic pangenomes. Nat Ecol Evol 8, 190–191 (2024). https://doi.org/10.1038/s41559-023-02276-6
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DOI: https://doi.org/10.1038/s41559-023-02276-6