Expansion of the genetic code can enable precise manipulation of proteins through selective functionalization of specific residues. Now, control of tryptophan interactions in proteins can be established by encoding of a vinyl-caged tryptophan analogue that can be selectively decaged to rescue protein activity.
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Haney, A.K., Cropp, T.A. Blocking and rescuing tryptophan interactions. Nat. Chem. 16, 485–486 (2024). https://doi.org/10.1038/s41557-024-01478-0
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DOI: https://doi.org/10.1038/s41557-024-01478-0