Aromatic oligoamide macrocycles have been developed in which the constrained backbone enforces hydrogen-bond donors to orient towards the macrocycle centre, forming a highly electropositive cavity. These macrocycles show strong binding for various anions and can partition into biomembranes to facilitate selective transmembrane anion transport.
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This is a summary of: Cao, R. et al. Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes. Nat. Chem. https://doi.org/10.1038/s41557-023-01315-w (2023).
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Rigid macrocycles with multiple hydrogen-bond donors for effective anion binding and transport. Nat. Chem. 15, 1501–1502 (2023). https://doi.org/10.1038/s41557-023-01316-9
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DOI: https://doi.org/10.1038/s41557-023-01316-9
