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DNA nanotechnology

Non-complementary computation

Molecular computing programmed with complementary nucleic acid strands allows the construction of sophisticated biomolecular circuits. Now, systems with partially complementary strands have been shown to enable more compact and faster molecular circuits, and may illuminate biological processes.

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Fig. 1: An AND logic gate implemented with strand displacement and strand commutation.

References

  1. Nikitin, M. P. Nat. Chem. https://doi.org/10.1038/s41557-022-01111-y (2023).

    Article  Google Scholar 

  2. Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).

    Article  CAS  Google Scholar 

  3. Dey, S. et al. Nat. Rev. Methods Primers 1, 1–24 (2021).

    Article  Google Scholar 

  4. Simmel, F. C., Yurke, B. & Singh, H. R. Chem. Rev. 119, 6326–6369 (2019).

    Article  CAS  Google Scholar 

  5. Zadeh, J. N. et al. J. Comput. Chem. 32, 170–173 (2011).

    Article  CAS  Google Scholar 

  6. Qian, L. & Winfree, E. Science 332, 1196–1201 (2011).

    Article  CAS  Google Scholar 

  7. Cherry, K. M. & Qian, L. Nature 559, 370–376 (2018).

    Article  CAS  Google Scholar 

  8. Song, T. et al. Nat. Nanotechnol. 14, 1075–1081 (2019).

    Article  CAS  Google Scholar 

  9. Zhang, J. X. et al. Nat. Chem. 10, 91–98 (2018).

    Article  Google Scholar 

  10. Chatterjee, G., Dalchau, N., Muscat, R. A., Phillips, A. & Seelig, G. Nat. Nanotechnol. 12, 920–927 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Grigory Tikhomirov.

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Petersen, P., Tikhomirov, G. Non-complementary computation. Nat. Chem. 15, 9–11 (2023). https://doi.org/10.1038/s41557-022-01115-8

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