Certain drug targets have been deemed undruggable because of the difficulty in finding pharmacologically useful inhibitors. Now, two teams have developed exciting technologies for the creation of diverse collections of macrocyclic molecules and have demonstrated their usefulness for discovering macrocyclic inhibitors.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Doak, B. C., Over, B., Giordanetto, F. & Kihlberg, J. Chem. Biol. 21, 1115–1142 (2014).
Neri, D. & Lerner, R. A. Annu. Rev. Biochem. https://doi.org/10.1146/annurev-biochem-062917-012550 (2018).
Josephson, K., Ricardo, A. & Szostak, J. W. Drug Discov. Today 19, 388–399 (2014).
Hamzeh-Mivehroud, M., Alizadeh, A. A., Morris, M. B., Church, W. B. & Dastmalchi, S. Drug Discov. Today 18, 1144–1157 (2013).
Usanov, D. L., Chan, A. I., Maianti, J. P. & Liu, D. R. Nat. Chem. https://doi.org/10.1038/s41557-018-0033–8 (2018).
Kale, S. S. et al. Nat. Chem. https://doi.org/10.1038/s41557-018-0042–7 (2018).
Heinis, C., Rutherford, T., Fruend, S. & Winter, G. Nat. Chem. Biol. 5, 502–507 (2009).
Walport, L. J., Obexer, R. & Suga, H. Curr. Opin. Biotechnol. 48, 242–250 (2017).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Iqbal, E.S., Hartman, M.C.T. Shaping molecular diversity. Nature Chem 10, 692–694 (2018). https://doi.org/10.1038/s41557-018-0095-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-018-0095-7