Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. Cell biologists now find another ageing-associated function for Rubicon — the release of exosomes containing microRNAs that control senescence and longevity.
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Zhen, Y., Stenmark, H. Exosome regulation by Rubicon in ageing. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01482-z
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DOI: https://doi.org/10.1038/s41556-024-01482-z