The different compartments of the mammary stem cell hierarchy develop into distinct breast cancer subtypes as a result of specific genetic lesions. A recent study identifies aberrant ERBB3low luminal progenitors with altered proteostasis and translation as the cell of origin of BRCA2-mutant breast cancer.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Visvader, J. E. Nature 469, 314–322 (2011).
Kuchenbaecker, K. B. et al. JAMA 317, 2402–2416 (2017).
Molyneux, G. et al. Cell Stem Cell 7, 403–417 (2010).
Joyce, R. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01315-5 (2024).
Nolan, E. et al. Nat. Med. 22, 933–939 (2016).
Balko, J. M. et al. Proc. Natl Acad. Sci. USA 109, 221–226 (2012).
Saxton, R. A. & Sabatini, D. M. Cell 168, 960–976 (2017).
Karaayvaz-Yildirim, M. et al. Sci. Adv. 6, eaay2611 (2020).
Liu, G. Y. & Sabatini, D. M. Nat. Rev. Mol. Cell Biol. 21, 183–203 (2020).
Hua, H. et al. J. Hematol. Oncol. 12, 71 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Xu, J., Liu, S. Cell origin of BRCA2-mutant breast cancer. Nat Cell Biol 26, 43–44 (2024). https://doi.org/10.1038/s41556-023-01322-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01322-6