The transcriptional coactivators TAZ and YAP pair with transcriptional enhanced associate domains (TEADs) to regulate transcription. TAZ and YAP nuclear condensates ensure optimal transcription. A new study reports that FUS regulates TAZ condensates by maintaining them in a fluid state to drive transcription of target genes.
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Hong, W. FUS maintains TAZ fluidity and function. Nat Cell Biol 26, 34–36 (2024). https://doi.org/10.1038/s41556-023-01318-2
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DOI: https://doi.org/10.1038/s41556-023-01318-2