β-adrenergic signalling induces thermogenesis in mature brown adipocytes through a well-known cAMP–protein kinase A (PKA) pathway and also promotes the growth and differentiation of new thermogenic adipocytes. A study now demonstrates that β-adrenergic agonists drive this pathway through a PKA-independent mechanism involving cAMP–EPAC1.
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E.D.R. consults for Novartis and is on the Advisory Board of Source Bio.
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Rosen, E.D. EPAC1 boosts thermogenic adipocyte formation. Nat Cell Biol 26, 39–40 (2024). https://doi.org/10.1038/s41556-023-01304-8
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DOI: https://doi.org/10.1038/s41556-023-01304-8