Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

Manganese controls lipoprotein secretion via biomolecular condensation

By regulating the condensation of the molecular transport machinery coat protein complex II (COPII), manganese ions contribute to the regulation of lipoprotein secretion and thereby the circulating lipid levels.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Manganese shifts the assembly-versus-dynamics balance of cellular COPII condensation.

References

  1. Goldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to statins. Cell 161, 161–172 (2015). A review on the roles of circulating cholesterol in cardiovascular diseases.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Jones, B. et al. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat. Genet. 34, 29–31 (2003). This paper reports mutations in SAR1B in individuals with chylomicron retention disease.

    Article  CAS  PubMed  Google Scholar 

  3. Wang, X. et al. Receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans. Cell Metab. 33, 350–366.e7 (2021). This paper reports a specialized lipoprotein export program.

    Article  CAS  PubMed  Google Scholar 

  4. Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Biomolecular condensates: organizers of cellular biochemistry. Nat. Rev. Mol. Cell Bio. 18, 285–298 (2017). A review on the emerging understanding of how biomolecular condensates contribute to cellular processes.

    Article  CAS  Google Scholar 

  5. Wang, Y. W. et al. Manganese therapy for dyslipidemia and plaque reversal in murine models. Life Metab. https://doi.org/10.1093/lifemeta/load040 (in the press). This paper reports that dietary manganese can contribute to ameliorate dyslipidaemia and atherosclerosis in mice.

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Wang, X. et al. Manganese regulation of COPII condensation controls circulating lipid homeostasis. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01260-3 (2023).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Manganese controls lipoprotein secretion via biomolecular condensation. Nat Cell Biol 25, 1732–1733 (2023). https://doi.org/10.1038/s41556-023-01300-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01300-y

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing