Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering the circulation. Here, we briefly review the state of research into mitochondria transfer, and discuss a methodological framework for studying the process.
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Acknowledgements
S.T. and C.C. and are supported by the National Institutes of Health (NIH) (grant R00-DK122019) and the American Heart Association (23IPA1054013). J.R.B. is supported by the NIH Office of the Director (DP5 OD028125) and Burroughs Wellcome Fund (CAMS 1019648).
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J.R.B. has pending and issued patents related to mitochondria transfer and obesity; has been a consultant for DeciBio and Flagship Pioneering within the past 12 months; receives royalties from Springer Nature; and is on the Scientific Advisory Board for LUCA Science.
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Nature Cell Biology thanks Martin Picard, Carlos Moraes and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Tiash, S., Brestoff, J.R. & Crewe, C. A guide to studying mitochondria transfer. Nat Cell Biol 25, 1551–1553 (2023). https://doi.org/10.1038/s41556-023-01246-1
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DOI: https://doi.org/10.1038/s41556-023-01246-1
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