The molecular program of human germline commitment remains largely unknown. A new study delineates the multifaceted functions of DMRT1 in human germline development, particularly in the transition from early to late primordial germ cells.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fs41556-023-01196-8/MediaObjects/41556_2023_1196_Fig1_HTML.png)
References
Li, L. et al. Cell Stem Cell 20, 858–873 (2017).
Tang, W. W. et al. Cell 161, 1453–1467 (2015).
Tang, W. W., Kobayashi, T., Irie, N., Dietmann, S. & Surani, M. A. Nat. Rev. Genet. 17, 585–600 (2016).
Irie, N. et al. Cell 160, 253–268 (2015).
Kojima, Y. et al. Cell Stem Cell 21, 517–532 (2017).
Chen, D. et al. Cell Rep. 25, 3591–3602 (2018).
Chen, D. et al. Cell Rep. 29, 4568–4582 (2019).
Sybirna, A. et al. Nat. Commun. 11, 1282 (2020).
Zarkower, D. Curr. Topics Dev. Biol. 102, 327–356 (2013).
Jorgensen, A., Nielsen, J. E., Blomberg Jensen, M., Graem, N. & Rajpert-De Meyts, E. Mol. Hum. Reprod. 18, 523–534 (2012).
Irie, N. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01224-7 (2023).
Jung, D. et al. Nat. Commun. 8, 15680 (2017).
Zhang, T. & Zarkower, D. Stem Cell Res. 24, 195–202 (2017).
Guo, J. et al. Cell Stem Cell 28, 764–778 (2021).
Kee, K., Angeles, V. T., Flores, M., Nguyen, H. N. & Reijo Pera, R. A. Nature 462, 222–225 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lu, Y., Yuan, P. & Qiao, J. DMRT1 drives the human germline forward. Nat Cell Biol 25, 1408–1410 (2023). https://doi.org/10.1038/s41556-023-01196-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01196-8