The cGAS–STING cytosolic double-stranded-DNA-sensing pathway provides protection against infection but also contributes to inflammatory pathology and thus must be tightly regulated. In this issue, Jie et al. find that endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L–HRD1 controls steady-state STING levels to limit STING-driven inflammation.
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K.F. is a scientific founder of Danger Bio, a Related Sciences company, and is a member of the scientific advisory board for Vesigen Therapeutics, NodThera, Janssen and Generation Bio. K.M.G. declares no competing interests.
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Gao, K.M., Fitzgerald, K.A. ERADication of STING limits inflammation. Nat Cell Biol 25, 635–636 (2023). https://doi.org/10.1038/s41556-023-01142-8
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DOI: https://doi.org/10.1038/s41556-023-01142-8