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Immunology

Telomeres are a life-extending gift

Nature Cell Biology volume 24, pages 1449–1450 (2022)Cite this article

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Cellular senescence induced by DNA replication and telomere attrition contributes to organ dysfunction, inflammation and impaired immunity. A study reveals that antigen-presenting cells provide telomeric DNA to CD4+ T cells in synaptic contact, which enables the suspension of senescence, T cell expansion and long-lived immunity.

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Fig. 1: APC donation of telomeres to T cells suppresses senescence and promotes long-term immunity.

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Authors and Affiliations

  1. Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

    Anna Carey, Laura Niedernhofer & Christina Camell

Authors
  1. Anna Carey
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  2. Laura Niedernhofer
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  3. Christina Camell
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Correspondence to Christina Camell.

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The authors report no competing interests.

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Carey, A., Niedernhofer, L. & Camell, C. Telomeres are a life-extending gift. Nat Cell Biol 24, 1449–1450 (2022). https://doi.org/10.1038/s41556-022-01004-9

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