Aggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 correlates with TDP-43 pathology.
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Ayala, Y.M., Grese, Z.R. Finding a chaperone for TDP-43. Nat Cell Biol 24, 1328–1330 (2022). https://doi.org/10.1038/s41556-022-00987-9
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DOI: https://doi.org/10.1038/s41556-022-00987-9
