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DNA REPAIR

Cohesin puts a break on distal homology hunt

Nature Cell Biology volume 23, pages 1112–1114 (2021)Cite this article

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During the repair of DNA breaks by homologous recombination, damaged DNA seeks out intact, similar in sequence segments to use as a template. In this issue, Piazza, Bordelet and colleagues describe three-dimensional chromosome architecture remodelling during homologous recombination and show that cohesin restricts homology search in cis, independently of sister chromatid cohesion.

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Fig. 1: Remodelling of 3D chromatin organization during HR and role of cohesin.

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Authors and Affiliations

  1. Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany

    Argyris Papantonis

  2. Institute of Molecular Biology (IMB), Mainz, Germany

    Vassilis Roukos

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  1. Argyris Papantonis
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  2. Vassilis Roukos
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Correspondence to Vassilis Roukos.

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The authors declare no competing interests.

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Papantonis, A., Roukos, V. Cohesin puts a break on distal homology hunt. Nat Cell Biol 23, 1112–1114 (2021). https://doi.org/10.1038/s41556-021-00791-x

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